As part of the National Aeronautics and Space Administration (NASA) initiated program on global civil aviation, NIST is assisting Federal Aviation Administration in its research to improve fire detection in aircraft cargo compartments. Aircraft cargo compartment detection certification methods have been reviewed. The Fire Emulator-Detector Evaluator (FE/DE) has been designed to evaluate fire detection technologies such as new sensors, multi-element detectors, and detectors that employ complex algorithms. The FE/DE is a flow tunnel that can reproduce velocity, temperature, smoke, and Combustion gas levels to which a detector might be exposed during a fire. A scientific literature survey and patent search have been conducted relating to existing and emerging fire detection technologies, and the potential use of new fire detection strategies in cargo compartment areas has been assessed. In the near term, improved detector signal processing and multi-sensor detectors based on combinations of smoke measurements, combustion gases and temperature are envisioned as significantly impacting detector system performance.